本系列专访聚焦抗体的特异性问题，采访了耶鲁大学杨晓勇教授、弗吉尼亚理工大学李立武教授、弗吉尼亚理工大学博士生Jocelyn S. Bodmer、弗吉尼亚理工大学博士生Con-Ning Yen等几位生物研究领域的专家学者。

本系列专访主要围绕以下三个问题展开：

1. 非特异性抗体对科研造成了哪些影响？

2. 为什么说基因敲除/沉默是验证抗体特异性的最好方法？

3. 如何用基因沉默验证抗体特异性？

该系列专访整理了他们的核心观点，期望您能和我们共同从中找到解决抗体问题的答案。

耶鲁大学杨晓勇教授

Dr. Xiaoyong Yang is a Professor of Comparative Medicine and of Cellular & Molecular Physiology at Yale University School of Medicine. He received B.S. from Nankai University, M.S. from Peking University, and Ph.D. from University of Alabama at Birmingham with Dr. Jeffrey Kudlow. He completed his postdoctoral training with Dr. Ronald Evans at The Salk Institute. Dr. Yang has published in Nature, Cell, Cell Metabolism, Molecular Cell, Genes & Development, PNAS, etc., and been frequently invited to speak at national and international conferences and academic institutions. Dr. Yang serves on scientific review panels for the NIDDK, NIGMS, NASA, American Diabetes Association, American Cancer Society, The Medical Research Council, The Wellcome Trust, National Natural Science Foundation of China, etc. Research in his laboratory is supported by The National Institutes of Health, The State of Connecticut, American Diabetes Association, American Heart Association, American Cancer Society and Ellison Medical Foundation.

弗吉尼亚理工大学李立武教授

Dr. Liwu Li is a professor in the Department of Biological Sciences and the Director of Program in Genetics, Biotechnology & Computational Biology at Virginia Tech. He received his Ph.D. degree in Cell and Molecular Biology from the University of Michigan. He is a regular member of the NIH Innate Immunity & Inflammation as well as Atherosclerosis and Vascular Inflammation Review Panels. Dr. Li’s studies focus on innate immune memory underlying both acute and chronic inflammation. His group has defined mechanisms governing the novel paradigms such as differential polarization and skewing of immune environment as well as priming and tolerance of macrophages. These dynamic paradigms play key roles during both the pathogenesis and resolution of human inflammatory diseases such as atheroschlerosis, sepsis, wound healing, and cancer.

Jocelyn S. Bodmer

Con-Ning Yen

弗吉尼亚理工大学博士生

弗吉尼亚理工大学博士生

抗体特异性专访